Publications
Select Publications
- Boocock, J., Alexander, N., Tapia, L. A., Walter-McNeill, L., Munugala, C., Bloom, J. S., & Kruglyak, L. (2023). Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction. bioRxiv : the preprint server for biology, 2023.12.07.570640.
- Guo, L., & Kruglyak, L. (2023). Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos. Physiological genomics, 55(11), 479–486.
- Kruglyak, L., Beyer, A., Bloom, J. S., Grossbach, J., Lieberman, T. D., Mancuso, C. P., Rich, M. S., Sherlock, G., & Kaplan, C. D. (2023). Insufficient evidence for non-neutrality of synonymous mutations. Nature, 616(7957), E8–E9.
- Zdraljevic, S., Walter-McNeill, L., Marquez, H., & Kruglyak, L. (2023). Heritable Cas9-induced nonhomologous recombination in C. elegans. microPublication biology, 2023, 10.17912/micropub.biology.000775.
- Zdraljevic, S., Walter-McNeill, L., Marquez, H., & Kruglyak, L. (2023). Cas9-induced nonhomologous recombination in C. elegans. bioRxiv : the preprint server for biology, 2023.01.19.524763.
- Swichkow, C. R., Bloom, J. S., & Kruglyak, L. (2022). Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications. PLoS biology, 20(12), e3001911.
- Dhindsa, R. S., Wang, Q., Vitsios, D., Burren, O. S., Hu, F., DiCarlo, J. E., Kruglyak, L., MacArthur, D. G., Hurles, M. E., & Petrovski, S. (2022). A minimal role for synonymous variation in human disease. American journal of human genetics, 109(12), 2105–2109.
- Schubert, O. T., Bloom, J. S., Sadhu, M. J., & Kruglyak, L. (2022). Genome-wide base editor screen identifies regulators of protein abundance in yeast. eLife, 11, e79525.
- Brandenberg, O. F., Schubert, O. T., & Kruglyak, L. (2022). Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression. Microbial cell factories, 21(1), 119.
- Guo, L., Bloom, J. S., Dols-Serrate, D., Boocock, J., Ben-David, E., Schubert, O. T., Kozuma, K., Ho, K., Warda, E., Chui, C., Wei, Y., Leighton, D., Lemus Vergara, T., Riutort, M., Sánchez Alvarado, A., & Kruglyak, L. (2022). Island-specific evolution of a sex-primed autosome in a sexual planarian. Nature, 606(7913), 329–334.
- Guo, L., Boocock, J., Hilt, E. E., Chandrasekaran, S., Zhang, Y., Munugala, C., Sathe, L., Alexander, N., Arboleda, V. A., Flint, J., Eskin, E., Luo, C., Yang, S., Garner, O. B., Yin, Y., Bloom, J. S., & Kruglyak, L. (2022). Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA. BMC genomics, 23(1), 260.
- Hilt, E. E., Boocock, J., Trejo, M., Le, C. Q., Guo, L., Zhang, Y., Sathe, L., Arboleda, V. A., Yin, Y., Bloom, J. S., Wang, P. C., Elmore, J. G., Kruglyak, L., Shrestha, L., Bakhash, S. A. M., Lin, M., Xie, H., Huang, M. L., Roychoudhury, P., Greninger, A., … Garner, O. B. (2022). Retrospective Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 74(2), 271–277.
- Adamson, P. C., Pfeffer, M. A., Arboleda, V. A., Garner, O. B., de St Maurice, A., von Bredow, B., Flint, J., Kruglyak, L., & Currier, J. S. (2021). Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California. Open forum infectious diseases, 8(11), ofab526.
- Guo, F., McClain, M., Zhao, X., Yi, K., Parmely, T., Unruh, J., Slaughter, B., Kruglyak, L., Guo, L., & Sánchez Alvarado, A. (2021). Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining. Journal of visualized experiments : JoVE, (175), 10.3791/62713.
- Bloom, J. S., Sathe, L., Munugala, C., Jones, E. M., Gasperini, M., Lubock, N. B., Yarza, F., Thompson, E. M., Kovary, K. M., Park, J., Marquette, D., Kay, S., Lucas, M., Love, T., Sina Booeshaghi, A., Brandenberg, O. F., Guo, L., Boocock, J., Hochman, M., Simpkins, S. W., … Arboleda, V. A. (2021). Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nature biomedical engineering, 5(7), 657–665.
- Guo, L., Bloom, J., Sykes, S., Huang, E., Kashif, Z., Pham, E., Ho, K., Alcaraz, A., Xiao, X. G., Duarte-Vogel, S., & Kruglyak, L. (2021). Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos. PLoS genetics, 17(6), e1009580.
- Ben-David, E., Boocock, J., Guo, L., Zdraljevic, S., Bloom, J. S., & Kruglyak, L. (2021). Whole-organism eQTL mapping at cellular resolution with single-cell sequencing. eLife, 10, e65857.
- Bloom, J. S., Sathe, L., Munugala, C., Jones, E. M., Gasperini, M., Lubock, N. B., Yarza, F., Thompson, E. M., Kovary, K. M., Park, J., Marquette, D., Kay, S., Lucas, M., Love, T., Booeshaghi, A. S., Brandenberg, O. F., Guo, L., Boocock, J., Hochman, M., Simpkins, S. W., … Arboleda, V. A. (2021). Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv : the preprint server for health sciences, 2020.08.04.20167874.
- Ben-David, E., Pliota, P., Widen, S. A., Koreshova, A., Lemus-Vergara, T., Verpukhovskiy, P., Mandali, S., Braendle, C., Burga, A., & Kruglyak, L. (2021). Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species. Current biology : CB, 31(5), 990–1001.e5.
- Boocock, J., Sadhu, M. J., Durvasula, A., Bloom, J. S., & Kruglyak, L. (2021). Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast. Science (New York, N.Y.), 371(6527), 415–419.
- Burga, A., Ben-David, E., & Kruglyak, L. (2020). Toxin-Antidote Elements Across the Tree of Life. Annual review of genetics, 54, 387–415.
- Renganaath, K., Chong, R., Day, L., Kosuri, S., Kruglyak, L., & Albert, F. W. (2020). Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross. eLife, 9, e62669.
- JS Bloom, J Boocock, S Treusch, MJ Sadhu, L Day, H Oates-Barker, L Kruglyak. Rare variants contribute disproportionately to quantitative trait variation in yeast. bioRxiv. 2019; 607291
- A Burga, E Ben-David, TL Vergara, J Boocock, L Kruglyak. Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nat Commun. 2019; 10, 110
- D Zeevi, JS Bloom, MJ Sadhu, AB Yehuda, D Zangen, E Levy-Lahad, L Kruglyak. Analysis of the genetic basis of height in large Jewish nuclear families. PLoS Genet. 2019; 15, e100808222
- L Gou, JS Bloom, L Kruglyak. The Genetic Basis of Mutation Rate Variation in Yeast. Genetics. 2019; Feb;211(2):731-740. doi: 10.1534/genetics.118.301609
- Karavani, E., Zuk, O., Zeevi, D., Barzilai, N., Stefanis, N. C., Hatzimanolis, A., Smyrnis, N., Avramopoulos, D., Kruglyak, L., Atzmon, G., Lam, M., Lencz, T., & Carmi, S. (2019). Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell, 179(6), 1424–1435.e8.
- Bloom, J. S., Boocock, J., Treusch, S., Sadhu, M. J., Day, L., Oates-Barker, H., & Kruglyak, L. (2019). Rare variants contribute disproportionately to quantitative trait variation in yeast. eLife, 8, e49212.
- Zeevi, D., Bloom, J. S., Sadhu, M. J., Ben Yehuda, A., Zangen, D., Levy-Lahad, E., & Kruglyak, L. (2019). Analysis of the genetic basis of height in large Jewish nuclear families. PLoS genetics, 15(7), e1008082.
- Burga, A., Ben-David, E., Lemus Vergara, T., Boocock, J., & Kruglyak, L. (2019). Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nature communications, 10(1), 2680.
- Gou, L., Bloom, J. S., & Kruglyak, L. (2019). The Genetic Basis of Mutation Rate Variation in Yeast. Genetics, 211(2), 731–740.
- FW Albert, JS Bloom, J Siegel, L Day, L Kruglyak. Genetics of trans-regulatory variation in gene expression. Elife. 2018; Jul 17;7. pii: e35471. doi: 10.7554/eLife.35471.
- MJ Sadhu, JS Bloom, L Day, JJ Siegel, S Kosuri, L Kruglyak. Highly parallel genome variant engineering with CRISPR-Cas9. Nat Genet. 2018; Apr;50(4):510-514. doi: 10.1038/s41588-018-0087-y
- A Burga, W Wang, E Ben-David, P Wolf, A Ramey, C Verdugo, K Lyons, P Parker, and L Kruglyak, A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017; 356
- E Ben-David, A Burga, L Kruglyak, A maternal-effect selfish genetic element in Caenorhabditis elegans. Science. 2017; Jun 9;356(6342):1051-1055. doi: 10.1126/science.aan0621
- MJ Sadhu, JS Bloom, L Day, L Kruglyak CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science. 2016; Vol. 352, Issue 6289, pp. 1113-1116 DOI: 10.1126/science.aaf5124.
- FW Albert, L Kruglyak The role of regulatory variation in complex traits and disease Nature Reviews Genetics (2015), doi:10.1038/nrg3891.
- KM Balla, EC Andersen, L Kruglyak, ER Troemel A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite PLoS pathogens (2015) 11 (2), e1004583-e1004583.
- S Treusch, FW Albert, JS Bloom, IE Kotenko, L Kruglyak Genetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae PLoS Genetics (2015) 11 (1), e1004913.
- X Wang, L Kruglyak Genetic Basis of Haloperidol Resistance in Saccharomyces cerevisiae Is Complex and Dose Dependent PLoS Genetics (2014) 10 (12), e1004894.
- Albert FW, Muzzey D, Weissman J, and Kruglyak L Genetic influences on translation in yeast PLoS Genetics (2014) 10 (10), e1004692.
- Heyne HO, Lautenschl?ger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg ?, Petretto E, Kruglyak L, P??bo S, Sch?neberg T, Albert FW Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression Genetics (2014) 198 (3): 1277-1290.
- JS Breunig, SR Hackett, JD Rabinowitz, L Kruglyak. (2014) Genetic basis of metabolome variation in yeast. PLoS genetics 10 (3), e1004142.
- EC Andersen, JS Bloom, JP Gerke, L Kruglyak. (2014) A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology. PLoS genetics 10 (2), e1004156.
- FW Albert, S Treusch, AH Shockley, JS Bloom, L Kruglyak. (2014) Genetics of single-cell protein abundance variation in large yeast populations. Nature 506 (7489), 494-497.
- C Reisser, C Dick, L Kruglyak, D Botstein, J Schacherer, DC Hess. (2013) Genetic basis of ammonium toxicity resistance in a sake strain of yeast: a Mendelian case. G3: Genes| Genomes| Genetics 3 (4), 733-740.
- EX Kwan, EJ Foss, S Tsuchiyama, GM Alvino, L Kruglyak, M Kaeberlein, MK Raghuraman, BJ Brewer, BK Kennedy, A Bedalov. (2013) A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS genetics 9 (3), e1003329.
- J.S Bloom, I.M. Ehrenreich, W. Loo, T.L. Vo Lite and L. Kruglyak. (2013) Finding the sources of missing heritability in a yeast cross. Nature 494, 234-237.
- A. Bendesky, J. Pitts, M.V. Rockman, L. Kruglyak and C.I. Bargmann (2012). Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in C. elegans. PLoS Genetics 8(12):e1003157.
- B.E. Gaertner, M.R. Parmenter, M.V. Rockman, L. Kruglyak and P.C. Phillips (2012). More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics 192:1533-42.
- R. Ghosh, A. Mohammadi, L. Kruglyak, W.S. Ryu. (2012) Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol. 2012 Oct 31;10 (1):85. [Epub ahead of print]
- Z. Khan, J.S. Bloom, S. Amini, M. Singh, D.H. Perlman, A.A. Caudy and L. Kruglyak (2012). Quantitative measurement of allele specific protein expression in a diploid yeast hybrid by LC-MS. Mol. Syst. Biol 8:602.
- M. L. Reaves, S. Sinha, J. Rabinowitz, L. Kruglyak, R.J. Redfield (2012) Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells. Science 337, 470-473.
- I.M. Ehrenreich, J.S. Bloom, N. Torabi, X. Wang, Y. Jia and L. Kruglyak (2012). Genetic architecture of highly complex chemical resistance traits across four yeast strains. PLoS Genetics e1002570. Published online 15 March 2012.
- N. Torabi, L. Kruglyak (2012) Genetic Basis of Hidden Phenotypic Variation Revealed by Increased Translational Readthrough in Yeast. PLoS Genetics 8(3) e1002546.
- R. Ghosh, E.C. Andersen, J.A. Shapiro, J.P. Gerke, L. Kruglyak. (2012) Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science Feb 3. 335(6068):574-8. Read the reprints of this article.
- E.C. Andersen, J.P. Gerke, J.A. Shapiro, J.R. Crissman, R. Ghosh, J.S. Bloom, M.A. F?lix, L. Kruglyak. (2012) Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet. Jan. 29 doi: 10.1038/ng.1050. [Epub ahead of print]
- E.J. Foss, D. Radulovic, S.A. Shaffer, D.R. Goodlett, L. Krugylak and A. Bedalov (2011). Natural genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biology 9(9): e1001144.
- E.X. Kwan, E. Foss, L. Kruglyak and A. Bedalov (2011). Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genetics 7(8): e1002250. Read the Full Text of this publication.
- N. Torabi and L. Kruglyak (2011). Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency inS. cerevisiae. PLoS Genetics 7(7): e1002211.
- H.S. Seidel, M. Ailion, J. Li, A. van Oudenaarden, M.V. Rockman and L. Kruglyak (2011). A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biology 9(7): e1001115. doi:10.1371/ journal.pbio.1001115.
- A. Bendesky, M. Tsunozaki, M. V. Rockman, L. Kruglyak, C. I. Bargmann. (2011) Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature. April 21.
- Z. Khan, S. Amini, J.S. Bloom, C. Ruse, A.A. Caudy, L. Kruglyak, M. Singh, D.H. Perlman and S. Tavazoie. (2011) Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome Biol. 12(12):R122.
- M. V. Rockman, S. Skrovanek, L. Kruglyak. (2010) Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science. Oct. 15; 330(6002):372-6. Read the Full Text of this publication.
- I. M. Ehrenreich, N. Torabi, Y. Jia, J. Kent, S. Martis, J. A. Shapiro, D. Gresham, A. A. Caudy, L. Kruglyak. (2010) Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature Letter, April 15. Read the Full Text of this publication.
- D. Gresham, B. Curry, A. Ward, D.B. Gordon, L. Brizuela, L. Kruglyak, D. Botstein. (2010) Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proc Natl Acad Sci USA. Jan 8. Read the Full Text of this publication.
- T. A. Manolio, F. S. Collins, N. J. Cox, D. B. Goldstein, L. A. Hindorff, D. J. Hunter, M. I. McCarthy, E. M. Ramos, L. R. Cardon, A. Chakravarti, J. H. Cho, A. E. Guttmacher, A. Kong, L. Kruglyak, E. Mardis, C. N. Rotimi, M. Slatkin, D. Valle, A. S. Whittemore, M. Boehnke, A. G. Clark, E. E. Eichler, G. Gibson, J. L. Haines, T. F. C. Mackay, S. A. McCarroll & P. M. Visscher (2009) Finding the Missing Heritability of Complex Diseases, Nature, Oct 8.
- L.N. Dimitrov, R.B. Brem, L. Kruglyak, D.E. Gottschling. (2009) Polymorphisms in Multiple Genes Contribute to the Spontaneous Mitochondrial Genome Instability of Saccharomyces cerevisiae S288C Strains. Genetics. Jul 6.
- L. Kruglyak, J.D. Storey. (2009) Cause and express. Nat Biotechnol. 2009 Jun;27(6):544-5.
- J.S. Bloom, Z. Khan, L. Kruglyak, M. Singh, A.A. Caudy. (2009) Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics. May 12;10:221.
- Z. Khan, J. S. Bloom, L. Kruglyak, M. Singh (2009). A Practical Algorithm for Finding Maximal Exact Matches in Large Sequence Data Sets Using Sparse Suffix Arrays; Bioinformatics 2009; doi:10.1093/ bioinformatics/btp275
- P.T. McGrath, M.V. Rockman, M. Zimmer, H. Jang, E.Z. Macosko, L. Kruglyak and C.I. Bargmann (2009). Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron Mar 12;61(5):692-9.
- M.V. Rockman and L. Kruglyak (2009). Recombinational Landscape and Population Genomics of C. elegans. PLoS Genetics. Mar;5(3):e1000419.
- J. Schacherer, J.A. Shapiro, D.M. Ruderfer and L. Kruglyak (2009). Comprehensive polymorphism survey elucidates population structure of S. cerevisiae. Nature. Mar 19;458(7236):342-5. link to commentary in Nature Highlights.
- K.C. Reddy, E.C. Andersen, L. Kruglyak, D.H. Kim. (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science. Jan 16;323(5912):382-4.
- M.F. Palopoli, M.V. Rockman, A. TinMaung, C. Ramsey, S. Curwen, A. Aduna, J. Laurita and L. Kruglyak (2008). Molecular basis of the copulatory plug polymorphism in C. elegans. Nature Aug 21;454(7207):1019-22. links to commentary in Current Biology and on Gene Expression blog.
- A. Demogines, E.N. Smith, L. Kruglyak and E. Alani (2008). Identification and dissection of a complex DNA repair sensitivity phenotype in bakers yeast.PLoS Genetics. Jul 11;4(7):e1000123.
- J. Zhu, B. Zhang, E.N. Smith, B. Drees, R. Brem, L. Kruglyak, R. Bumgarner and E.E. Schadt (2008). Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat. Genet. (published online 15 June 2008; doi:10.1038/ng.167).
- M.V. Rockman and L. Kruglyak (2008). Breeding designs for recombinant inbred advanced intercross lines. Genetics (published online May 27, 2008; doi:10.1534/genetics.107.083873).
- E.N. Smith and L. Kruglyak (2008). Gene-environment interaction in yeast gene expression. PLoS Biol 6(4): e83. doi:10.1371/journal.pbio.0060083.
- L. Kruglyak (2008). The road to genome-wide association studies. Nat. Rev. Genet. 9:314-318 (published online 19 February 2008; doi:10.1038/nrg2316).
- H.S. Seidel, M.V. Rockman and L. Kruglyak (2008). Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science319:589-594 (published online on Science Express January 10, 2008; doi:10.1126/science.1151107). links to commentaries: Nature Reviews Genetics, Nature, This Week in Science, Nature Highlights
- E.J. Foss, D. Radulovic, S.A. Shaffer, D.M. Ruderfer, A. Bedalov, D.R. Goodlett and L. Kruglyak (2007). Genetic basis of proteome variation in yeast. Nat. Genet. 39:1369-1375 (published online 21 October 2007; doi:10.1038/ng.2007.22).
- J. Schacherer, D. Ruderfer, D. Gresham, K. Dolinski, D. Botstein and L. Kruglyak (2007). Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS ONE 2(3): e322. doi:10.1371/journal.pone.0000322.
- Perlstein, Ruderfer, Roberts, Schreiber, Kruglyak (2007). Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat. Genet. 39:496-502.
- Rockman, Kruglyak (2006). Genetics of global gene expression. Nat. Rev. Genet. 7:862-72.
- Ruderfer, Pratt, Seidel, Kruglyak (2006). Population genomic analysis of outcrossing and recombination in yeast. Nat. Genet. 38:1077-1081.
- Riehle, Markianos, Niare, Xu, Li, Toure, Podiougou, Oduol, Diawara, Diallo, Coulibaly, Ouatara, Kruglyak, Traore, Vernick (2006). Natural malaria parasite infection in Anopheles gambiae is regulated by a single genomic control region. Science 312:577-579.
- Gresham, Ruderfer, Pratt, Schacherer, Dunham, Botstein, Kruglyak (2006). Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science 311:1932-1936.
- Perlstein, Ramachandran, Ruderfer, Haggarty, Kruglyak, Schreiber (2006). Revealing complex traits using small molecules and naturally recombinant yeast strains. Chem Biol. 13:319-327.
- Kruglyak (2005). Power tools for human genetics. Nature Genet. 37:1299-1300.
- Ronald, Brem, Whittle, Kruglyak (2005). Local regulatory variation in Saccharomyces cerevisiae. PLoS Genetics 1(2):e25.
- Storey, Akey, Kruglyak (2005). Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol. 3(8):e267.
- Brem, Storey, Whittle, Kruglyak (2005). Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 436:701-703.
- Brem, Kruglyak (2005). The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc. Natl. Acad. Sci. USA 102:5 1572-1577.
- Ronald, Akey, Whittle, Smith, Yvert, Kruglyak (2005). Simultaneous genotyping, gene expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res. 12:284-291.
- Akey, Eberle, Rieder, Carlson, Shriver, Nickerson, Kruglyak. (2004). Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol. 2(10):e286.
- Parker, Kim, Sutter, Carlson, Lorentzen, Johnson, DeFrance, Ostrander, Kruglyak (2004). Genetic structure of the purebred domestic dog. Science304:1160-1164.
- Carlson, Eberle, Kruglyak, Nickerson (2004). Mapping complex disease loci in whole-genome association studies. Nature 429:446-452.
- The International HapMap Consortium (2003). The International HapMap Project. Nature 426:789-796.
- Yvert, Brem, Whittle, Akey, Foss, Smith, Mackelprang, Kruglyak (2003). Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat. Genet. 35:57-64.
- Carlson, Eberle, Rieder, Smith, Kruglyak, Nickerson (2003) Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet 33:518-521.
- Niar?, Markianos, Volz, Oduol, Tour?, Bagayoko, Sangar?, Traor?, Wang, Blass, Dolo, Bouar?, Kafatos, Kruglyak, Tour?, Vernick (2002) Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population. Science 298: 213-216.
- Brem, Yvert, Clinton, Kruglyak (2002) Genetic dissection of transcriptional regulation in budding yeast. Science 296:752-755.
- Eberle, Pf?tzer, Pogue-Geile, Bronner, Crispin, Kimmey, Duerr, Kruglyak, Whitcomb, Brentnall (2002) A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet 70:1044-1048.
- Ardlie, Liu-Cordero, Eberle, Daly, Barrett, Winchester, Lander, Kruglyak (2001) Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet69:582-589.
- Kruglyak, Nickerson (2001) Variation is the spice of life. Nature Genetics27:234-236.
- Kruglyak (1999) Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet 22:139.
- Kruglyak (1997) The use of a genetic map of biallelic markers in linkage studies. Nat Genet 17:21
- Kruglyak, Daly, Reeve-Daly, Lander (1996) Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58:1347.
- Lander, Kruglyak (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241.