The Kruglyak Lab conducts experiments in model organisms, as well as computational analyses, aimed at understanding how changes at the level of DNA are shaped by molecular and evolutionary forces, and how these changes lead to all the observable differences among individuals within a species.

Dr. Kruglyak has also been an Investigator with the Howard Hughes Medical Institute (HHMI) since 2008, working towards understanding the genetic basis of phenotypic variation in species.